2,5-Furandicarboxylic acid (FDCA) is a dicarboxylic acid compound (figure 1) that is currently recognized as one of the most important “platform molecules” due to its potential application as a monomer in the synthesis of green polymers. Furthermore, with the similar molecular structure, 2,5-furandicarboxylic acid is expected as a green alternative polymer building block to the wildly used purified terephthalic acid (PTA) in the production of polyesters and polyamides. In addition, 2,5-furandicarboxylic acid is naturally found in human urine, and has been used in pharmacology, metal-organic framework materials, and organic synthesis.
Fig. 1 The chemical structure of 2,5-furandicarboxylic acid
Synthesis of 2,5-Furandicarboxylic Acid
Conversion of biomass into value-added fuels and chemicals is garnering increased attention, and many new catalysts and methods have been developed recently. For instance, 2,5-furandicarboxylic acid can be synthesized from substrates like, 5-hydroxymethylfurfural (HMF), 5-methoxymethylfurfural (MMF), furfural or others via many catalytic methods, such as chemo-catalysis, bio-catalysis, photocatalysis and electrocatalysis, as shown in figure 2[1]. While bio-catalysis is a promising approach with the advantages of mild reaction condition, lower cost, higher selectivity, and environment amity.
Fig. 2 Catalytic conversion of lignocellulosic biomass-derived furans into 2,5-furandicarboxylic acid (FDCA)
Among the various pathways, the most common method to synthesize 2,5-furandicarboxylic acid from lignocellulosic biomass is the catalytic oxidation of 5-hydroxymethylfurfural. Lignocellulose comes from waste streams such as agriculture, forestry, and paper and it is a composite of three types of materials: lignin, cellulose, and hemicellulose. The acid-catalyzed hydrolysis of cellulose and hemicellulose produces glucose, fructose, and xylose, which can be dehydrated to produce the platform chemicals 5-hydroxymethylfurfural and furfural. The classical oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid occurs via an easy pathway, as shown in figure 3.
Fig. 3 Conventional synthesis and oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid
Polymers Derived from 2,5-Furandicarboxylic Acid
2,5-Furandicarboxylic acid is an aromatic compound that is employed heavily in the synthesis of polyester, polyamide, epoxy resin, and other polymers, as shown in figure 4[2]. 2,5-Furandicarboxylic acid has been proved to be a promising bio-based building block that is expected to substitute terephthalic acid.
Fig. 4 Different polymers derived from 2,5-furandicarboxylic acid
Our 2,5-Furandicarboxylic Acid
Our 2,5-furandicarboxylic acid is derived from oxidation of 5-hydroxymethylfurfural (HMF). And it is a renewable green alternative to petroleum-based terephthalic acid.
| Product Name | 2,5-furandicarboxylic acid, bio-based FDCA |
| Catalog | BIOS3238402 |
| Appearance | White powder |
| CAS No. | 3238-40-2 |
| Molecular formula | C6H4O5 |
| Molecular weight | 156.09 |
| Melting point | ＞310°C |
| Boiling Point | 419.2°C |
| Relative Density | 1.604 |
| Stability | Stable at room temperature, airtight storage in a cool and dry environment |
| Applications | It can be used as a monomer to synthesize polyester, polyamide, epoxy resin, and other polymers. |
Alfa Chemistry is a professional supplier of biosynthetic 2,5-furandicarboxylic acid. For high quality products, professional technical service, use suggestion and latest industry news, please feel free to contact us.
References
- Yuan, H., Liu, H., Du, J., Liu, K., Wang, T., & Liu, L. Biocatalytic production of 2,5-furandicarboxylic acid: recent advances and future perspectives. Applied Microbiology and Biotechnology, 2019.
- Fei X, Wang J, Zhang X, Jia Z, Jiang Y, Liu X. Recent Progress on Bio-Based Polyesters Derived from 2,5-Furandicarbonxylic Acid (FDCA). Polymers (Basel). 2022 Feb 6;14(3):625.
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