Fermentation Process Development and Optimization

Microbial fermentation refers to the process of preparing the microbial organism itself, or metabolites, by means of the life activity of microorganisms in aerobic or anaerobic conditions. Microbial fermentations have been utilized to produce chemicals, materials, biofuels, foods and medicines for many years. Although, fermentation processes are used from generations, the need for sustainable production of products and to meet the market requirements in a cost-effective manner have put forward a challenging demand.

Alfa Chemistry has a complete suite of fermentation development services to help ensure the commercial viability of target strains through basal culture, scale-up, optimization and other steps.

Process Development and Optimization Services

Alfa Chemistry performs fermentation development and optimization services primarily through the followings: design and optimization of the fermentation condition, fermentation medium optimization, scale-up.

Fermentation condition

Alfa Chemistry is dedicated to process development and optimization in the field of industrial fermentation. Design and optimization services of fermentation conditions we can offer include:

• Dissolved oxygen (DO) concentration and DO supplying condition.
• Fermentation technical parameters (pH, temperature, agitation speed, etc.).
• Replenishment process.
• Fermentation equipment.

Fermentation medium optimization

• Fermentation medium optimization is one of the most critically investigated phenomenon that is carried out before any large-scale metabolite production and possess many challenges.
• Generally, carbon and nitrogen sources present in the medium can influence the metabolite production.
• Optimization technique (Click)

Scale-up and pilot scale production

Alfa Chemistry can provide our customers with professional technical services for process design and equipment design of scale-up production. We can provide pilot scale production services as well.

• Experience in handling 3,000+ microbial strains.
• Equipped with fermenters from 50 to 10,000L.
• Skilled in fermentation, separation, drying and other fermentation production processes.

Service Process

• Quotation—Submit a request for quotation.
• Contact—A technical manager will contact you within 24 hours.
• Placing an order—You will review and approve the final price and place an order.
• Payment—Confirm with you and make the payment.
• Samples and forms—Instruct you to ship your samples and form.
• Results and post-services—Send results according to the specific service items and make a perfect post-services.

Reference

1. Singh, V., Haque, S., Niwas, R., Srivastava, A., Pasupuleti, M., & Tripathi, C. K. M. Strategies for Fermentation Medium Optimization: An In-Depth Review. Frontiers in Microbiology, 2017, 7.

Our products and services are for research use only.