L-Isoleucine

L-isoleucine is recognized as one of the essential amino acids crucial for numerous bodily functions. As a branched-chain amino acid (BCAA), alongside leucine and valine, it plays a pivotal role in protein synthesis, muscle metabolism, energy balance, and immune system performance. At Alfa Chemistry, we offer biobased L-isoleucine sourced from natural, renewable plant-based origins, setting it apart from synthetic alternatives that rely on non-renewable resources.

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The Biosynthesis of L-Isoleucine

L-isoleucine is primarily produced through microbial fermentation, with Corynebacterium glutamicum being the main production strain. The biosynthetic pathway of L-isoleucine in C. glutamicum is intricate and involves several key enzymatic reactions. The pathway starts with L-aspartate, derived from oxaloacetate in the tricarboxylic acid (TCA) cycle, and includes ten reactions leading to the formation of L-isoleucine. These reactions are intertwined with the synthetic pathways of other amino acids like L-lysine, L-methionine, L-threonine, L-valine, L-leucine, and D-pantothenic acid. The biosynthesis of L-isoleucine in C. glutamicum is a complex and regulated process that requires precise control of enzyme activities and gene transcription.

The biosynthetic pathway of L-isoleucine in C. glutamicum^[1]

Applications of L-Isoleucine

The versatility of L-isoleucine extends to various industries, impacting pharmaceuticals, food and beverages, animal feed, cosmetics, and nutritional supplements. In pharmaceutical formulations, it is utilized in intravenous solutions, parenteral nutrition, and medications aimed at addressing muscle-related and metabolic issues. Within the food and beverage sector, L-isoleucine fortifies functional foods, sports nutrition supplements, and beverages catering to consumers seeking enhanced physical performance and overall well-being. Moreover, the animal feed industry leverages L-isoleucine to enhance the nutritional value of livestock feed, promoting growth and ensuring proper protein synthesis in cattle and poultry.

Choose Alfa Chemistry

Alfa Chemistry is a leading provider of high-quality and sustainable biobased L-isoleucine. By utilizing environmentally friendly processes, we offer a renewable and eco-friendly alternative to traditionally synthesized L-isoleucine. Our biobased L-isoleucine is produced in a controlled and efficient manner, ensuring consistency and purity in every batch. Contact us today to learn more about our sustainable biobased L-isoleucine and explore how it can benefit your products and processes.

Reference

1. Wang, Xiaoyuan. Strategy for improving L-isoleucine production efficiency in Corynebacterium glutamicum. Applied microbiology and biotechnology, 2019, 103: 2101-2111.

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